Disease model animals
An animal model to study Alzheimer’s disease
the most common degenerative neurological disease with worsening memory and cognitive function
An animal model to study Parkinson’s disease
The second common degenerative neurological disease which affects dopaminergic neuron and reduce the amount of dopamine in brain. The symptoms include shaking, rigidity, slowness of movement and difficulty with walking, and those come slowly. Dogs and cats are the only animals which develop Parkinson’s disease.
Flexed posture of the transgenic dog, Rigid and contracted legs
Unable to ease of movement in knuckling test
Normal dog’s brain (MRI)
Abnormal brain of Parkinson’s disease model dog
An animal model to study neurodegenerative disease
Mediclone produces neurodegenerative disease model animals. There are many global biomedical companies to develop new medicines of neurological diseases competitively. However, it is difficult to enter clinical trials from pre-clinical researches because of the lack of medium/large disease model animals to test new drugs in pre-clinical trials. Dogs have many similarity to human such as lifespan, body organs, and the number of genetic diseases. Moreover dogs are possible to test cognitive and motor ability that makes dogs more attractive as a neurodegenerative disease animal model compared to the mice which have been used as a disease model animal in many researches and have many limitations to be used in pre-clinical researches.
An customized disease model animal
To test the efficacy of new drugs by using customized animal disease models such as diabetes, high blood pressure, cancer or etc.